Our favorite vaccine expert is less than impressed with evidence to support the Omicron BA.4/5 "bivalent" booster shots now rolling out for everyone 12 and older. A must-watch deep dive into some science, here on Locals FIRST!
We also talk polio and monkeypox and flu 👍 Seriously, this interview 🤯
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Topics & Timestamps:
00:00 Intro
1:10 A brief history of the Covid vaccines, groups that benefit from boosting
5:12 Incubation periods and vaccination "goals," preventing infection vs. severe disease
10:54 Bivalent vaccine, the FDA's EUA approach, crucial dosing issues (ancestral strain vs. bivalent)
17:15 BA.4/5 booster immunogenicity data (or lack thereof), mouse data & vax safety profile
21:40 Why Paul himself would pass on the new booster, incubation periods, why Covid zero is a fantasy
24:28 Paul's "perfect" bivalent vaccine
25:37 Yearly targeted boosters, myocarditis and the Thai children's study
28:39 BA.4/5: MIS-C, boosters & long Covid, data from JAMA's Italian study
31:28 Comparing BA.4/5 & the yearly flu vax, timing of the yearly flu shot
38:45 Polio's resurgence, injected inactivated vs. live oral polio vaccines, the role of sanitation
48:05 Monkeypox and a history of smallpox vaccines
56:43 Reflection w/Dr. Offit: what he's gotten right, what he's gotten wrong and where to go from here
1:01:57 Final thoughts
Mrs. DoggMD and I hiked up to the top of a crazy temple and cemetery called Otani Sobyo above Kyoto this morning. Pure madness 🔥 and HELLLA G-HOSTS!
Today's interview with legendary vaccine researcher Paul Offit. Video version coming shortly!
For your intergalactic enjoyment of the now:😆😆
https://www.instagram.com/reel/DezbWJOtnzj/?obrf=d3hqb3c1OWo0M2Rj
Another VPZD Show! https://zdoggmd.com/podcasting/vpzd-46/
Topics covered:
Clarifying brain death versus severe brain damage, and why a competent examiner matters
Zubin’s first travel speaking engagement in three years, a pain medicine panel in Dallas, and the Rodeo Goat burger
Vinay’s panel at a biotech conference and the longevity target question
Elizabeth Holmes and Theranos, and how John Ioannidis spotted the lack of peer reviewed papers
Why you can’t run 100 tests off a single drop of blood
Zubin’s Theranos lipid panel at TEDMED and whether the numbers were real
Finger sticks versus venipuncture, and why lancets hurt
The Nathan Fielder documentary and the 35 days before federal prison
Holmes’s personality, her belief that the machine works, and “Theranos 2.0”
Puppeteer or puppet: Billy Evans, Sunny Balwani, and the men in her life
Amanda Seyfried’s reenactments and the second half of the film
Did she commit fraud, did it harm patients, and was she scapegoated for flying too high
Why Holmes...
